Fusidic Acid, Inj/Oral

Other Anti-infective Preps · Antibacterial

Indications

Staphylococcal infections.

Dosage

INFUSION: Adults: In severe infection, 500 mg three times daily by slow IV infusion. Children: < 50 kg: 6-7 mg/kg three times daily. Neonates: 10 mg/kg every 12 hr. ORAL: Adults: 500 mg three times daily. Children: Up to 1 yr, 50 mg/kg daily in 3 divided doses; 1-5 yr, 250 mg three times daily; 5-12 yr, 500 mg three times daily; above 12 yr, same as adult.

Administration

Administer by IV and infused slowly over a period of not less than 6 hrs. Reconstitution: Dissolve the contents of one vial containing 580 mg diethanolamine fusidate powder in the 50 mL buffer provided and then for adults add this to 500 mL appropriate infusion fluid, The enclosed needle may be used for this purpose. For Paeds & Adults < 50 kg: Each dose corresponds to approx 0.6 mL of the fusidate/buffer solution per kg body wt. This volume should be further diluted, at least tenfold, with the appropriate infusion fluid and infused slowly over a period of not less than 6 hours. Compatibility: NaCl, D5W.

Adverse Effects

Reversible jaundice. Gl disturbances.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Positive evidence of risk: Use only when no safer alternative exists for a serious problem. Lactation: Caution advised or effect undetermined. Precautions: Perform periodic liver function tests.

Advice to Patient

Take with meals. If you miss a dose, take it as soon as you remember unless it is almost time for the next dose. Do not take double dose. Discontinue medication if jaundice occurs. Contact prescriber if there is no improvement or worsening of condition. Frequent laboratory tests may be required during treatment, get them done as recommended by the physician.

Pharmacokinetics

Absorption: Sodium fusidate: Well absorbed from the GI tract. Oral suspensions are less well absorbed. Metabolism: Hepatic. Bioavailability: Sodium fusidate: 70%. Half-life elimination: Plasma: 10-15 hrs. Elimination: 5-6 hrs. Time to peak, plasma: 2-4 hrs. Excretion: Faeces (mainly). Urine (small amounts).

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.