Fosfomycin

Other Anti-infective Preps · Antibiotic

Indications

Infections of eye, ENT, respiratory tract, gastro- intestinal tract, urinary tract, obstetrics & gynaecology, skin & soft tissues by fosfomycin sensitive pathogens.

Dosage

ORAL: Adults: Usually 500 mg 6 hourly. Children: Usually 250 mg 6 hourly. INJECTION: Adults: IM 1 gm every 8 hr. IV 1-4 gm every 8 hr. Children: IM 500 mg every 8 hr. IV 1-2 gm every 8 hr. Infants: IM 250 mg every 8 hr. IV 100-400 mg/kg/day.

Administration

Administer via IV route. The duration of infusion should be at least 15 mins for 2 gm, at least 30 mins for 4 gm and at least 60 mins for 8 gm. Use only clear solutions. As damaging effects can result from inadvertent intra-arterial administration of products not specifically recommended for intra-arterial therapy, it is essential to ensure that drug is only administered into veins. The duration of treatment depends on the individual response of the pathogens and the patient´s clinical outcome.

Adverse Effects

Headache, rash, diarrhoea, nausea, vomiting, anorexia, epigastric discomfort, dizziness, drowsiness, fatigue, pruritus.

Risk Factor (Pregnancy/Lactation)

Pregnancy: No evidence of risk in humans. Lactation: Contraindicated or not recommended.

Interactions

Antacids, metoclopramide and drugs altering GI motility.

Advice to Patient

Take 1 hour before or 2 hours after meals. After reconstitution, take drug immediately after it dissolves. Do not take dry granules or mix them with hot water. Contact prescriber if there is severe diarrhoea that remains for 3 or more days. Watery or bloody stools can occur 2 or more months after therapy and can be serious, requiring immediate treatment. Go to prescriber for further urine testing after taking fosfomycin.

Pharmacokinetics

Absorption: Poorly absorbed from the GI tract. Metabolism: Not metabolized. Bioavailability: 30%-40%. Half-life elimination: 2 hrs. Time to peak, plasma: 4 hrs. Excretion: Urine (mainly).

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.