Flurbiprofen, Oral

Anti-rheumatic, Systemic · NSAID

Indications

Rheumatoid diseases, osteoarthrosis, ankylosing spondylitis.

Dosage

Adults: 150-200 mg daily in divided doses; max 300 mg daily. Children: Not recommended.

Adverse Effects

Gl intolerance, rash, rarely jaundice, thrombocytopenia, oedema, mouth ulcers, dizziness, visual disturbance.

Risk Factor (Pregnancy/Lactation)

Pregnancy: No evidence of risk in humans. Lactation: Contraindicated or not recommended. Contraindications: Active peptic ulcer, Gl bleeding. Aspirin/anti-inflammatory induced allergy. Precautions: Asthma. Renal , cardiac, or hepatic impairment. Hypertension, bleeding disorders.

Interactions

Furosemide, anticoagulants, other NSAIDs, lithium, mifepristone, antihypertensives, quinolones.

Advice to Patient

Take with or without meals. To reduce GI upset, take with meals. Do not crush tablets. Swallow whole with a glass of water. Discontinue medication and inform prescriber if there is constant stomach pain/cramps, blood in stool. Contact prescriber if there is unusual cough, difficulty in breathing, fast heartbeat, chest pain, palpitations, blood in urine/stool/mouth, unusual bruising or bleeding, skin rash, itching, blisters, fever, swelling in extremities, ringing in ears, changes in hearing, acute fatigue, yellowing of skin or eyes, difficulty in speaking, indigestion. Avoid smoking and alcohol during therapy. Do not take aspirin, aspirin containing medications, anti-inflammatory medications without consulting prescriber. Take sufficient amount of fluids (2-3 litres per day) to maintain hydration, unless restricted by the prescriber. Check your weight every week and report unusual…

Pharmacokinetics

Onset: 1-2 hrs. Rapidly and non-stereoselectively. Absorption: Oral: Readily absorbed from the GI tract. Metabolism: Hepatic. Bioavailability: 96%. Half-life elimination: 3-6 hrs. Time to peak, plasma: 1-2 hrs. Excretion: Urine (mainly).

Brands with this active ingredient

• Algopit
• Alivio
• Anaf
• Anorcid
• Ansaid
• Arbiprofen
• Arflur
• Benprofen
• Biprotec
• Confen
• Curadol
• Dansaid
• Dentifen
• Dentofen
• Dulpro

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.