Etifoxine

Tranquilizer, Sedative/Hypnotic · Benzoxazine

Indications

Psychosomatic manifestations of anxiety such as autonomic dystonia, notably of a cardiovascular nature. Chemotherapy-induced pain. Fear, increased irritability, decreased mood.

Dosage

Adults: 150-200 mg/day. Max duration: 12 wks. Children: Not recommended.

Adverse Effects

Drowsiness, maculopapular rash, erythema multiforme, itching, facial oedema.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Shock, myasthenia gravis, severe hepatic impairment, severe renal impairment, galactosaemia, glucose-galactose malabsorption syndrome, lactase deficiency.

Interactions

Opioid analgesics, barbiturates, opiates, antihistamines, neuroleptics, antitussives.

Advice to Patient

Swallow whole cap with little amount of water. Due to risk of drowsiness, avoid driving and other tasks that require mental alertness.

Pharmacokinetics

Absorption: Rapidly absorbed by the GI tract. Metabolism: Hepatic. Half-life elimination: 6 hrs. Active metabolite (Diethyl-etifoxine): Approx. 20 hrs. Time to peak: 2-3 hrs. Excretion: Urine. Bile.

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.