Ephedrine, Inj/Oral

Bronchodilator & Anti-asthma Preps: Orals/Parenterals · Sympathomimetic

Indications

Bronchial spasm.

Dosage

INJECTION: Adults: 25-50 mg SC/IM/IV. Children: Reversal of hypotension from epidural and spinal anaesthesia: IV injection of a solution containing ephedrine hydrochloride 3 mg/mL: 1-12 yr, 500-750 mcg/kg or 17-25 mg/square meter every 3-4 minutes according to response, max 30 mg during episode; 12-18 yr, 3-7.5 mg, max 9 mg repeated every 3-4 minutes according to response, max 30 mg during episode. ORAL: Adults: 15-30 mg three times daily. Children: Over 4 yr, 10 mg three times daily.

Administration

Administer by SC, IM or slow IV route. Compatibility: Physically compatible with D5W, D10W, Ringer solution, LR, NS, 0.45% NS.

Adverse Effects

Anxiety, restlessness, insomnia, tremor, arrhythmia, tachycardia, nausea, dry mouth, cold extremities.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Risk cannot be ruled out. Lactation: Caution advised or effect undetermined. Contraindications: Hyperthyroidism, hypertension, coronary disease, prostatic hypertrophy, hyperexcitibility, closed angle glaucoma. Precautions: Diabetes. Renal impairment.

Interactions

MAOIs, anaesthetics, TCADs, B blockers, oxytocin, guanethidine, digoxin, ergotamine, dexamethasone, theophylline.

Pharmacokinetics

Onset: Oral: 15-60 mins. IV: 5 mins. IM, SC: 10-20 mins. Duration: Oral: 3-5 hrs. IV: 1 hr. IM, SC: 30-60 mins. Absorption: Readily and completely absorbed from the GI tract. Metabolism: Hepatic. Bioavailability: Oral: 88%. Half-life elimination: 3-6 hrs. Time to peak, plasma: 2 hrs. Excretion: Urine.

Brands with this active ingredient

• Aksidrin
• Efed
• Efedra
• Elidrine
• Ephedra
• Ephedrine
• Ephedrine
• Ephedrine
• Sedaphrine

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.