Domperidone maleate and Cinnarizine

Antiemetic & Gastroprokinetic · Antidopaminergic/Piperazine derivative

Indications

Epigastric sense of fullness, upper abdominal distention, regurgitation. Nausea and vomiting.

Dosage

ORAL: Adults: All indications: 10-20 mg orally 3-4 times daily before meals; max 80 mg daily. Re-evaluate need for continued treatment after 4 wk. Children: Not recommended.

Adverse Effects

Rarely GI upset, weight gain, drowsiness, dry mouth, sweating, lichen planus, lupus-like skin reaction, raised serum prolactin, allergic reactions.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Porphyria. Precautions: Renal or hepatic impairment, Parkinson's disease.

Interactions

Ketoconazole, ritonavir, erythromycin, alcohol, CNS depressants, TCADs.

Pharmacokinetics

DOMPERIDONE: Absorption: Rapid. Metabolism: Hepatic (rapid and extensive). Bioavailability: Absolute bioavailability: Oral: 15%. IM: 90%. Half-life elimination: 7.5 hrs. Hepatic impairment: 15-23 hrs. Renal impairment: 7.4-20.8 hrs. Time to peak, plasma: 1 hr after dosing. Excretion: Urine (30% of an oral dose). Faeces (66%). CINNARIZINE: Absorption: Absorbed from GI tract. Metabolism: Extensively metabolized via N-dealkylation. Bioavailability: Low and variable. Half-life elimination: 3-6 hrs. Time to peak, plasma: Oral: 2-4 hrs. Excretion: Faeces (mainly as unchanged drug). Urine (predominantly as metabolites).

Compiled by Healify Pharmacy from published drug references. How we compile it →

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