Domperidone Maleate

Antiemetic & Gastroprokinetic · Antidopaminergic

Indications

Epigastric sense of fullness, upper abdominal distention, regurgitation. Nausea and vomiting.

Dosage

Adults: All indications: 10-20 mg orally 3-4 times daily before meals; max 80 mg daily. Re-evaluate need for continued treatment after 4 wk. Children: Only Nausea & Vomiting: 0.25-0.5 mg/kg body-wt, 3-4 times daily; max 2.4 mg/kg daily.

Adverse Effects

Rarely, GI upset, raised serum prolactin.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Prolactinoma, GI haemorrhage, perforation or obstruction, hepatic impairment. Precautions: Renal impairment.

Interactions

Ketoconazole, ritonavir, erythromycin.

Pharmacokinetics

Absorption: Rapid. Metabolism: Hepatic (rapid and extensive). Bioavailability: Absolute bioavailability: Oral: 15%. IM: 90%. Half-life elimination: 7.5 hrs. Hepatic impairment: 15-23 hrs. Renal impairment: 7.4-20.8 hrs. Time to peak, plasma: 1 hr after dosing. Excretion: Urine (30% of an oral dose). Faeces (66%).

Brands with this active ingredient

• Avifix Maleate
• Dom Retard
• Dome-One Maleate
• Domel
• Domileate
• Domwis
• Donarin Plus
• Dopedom
• Dypin-V
• Dyril V
• Emiset
• Emolium Tab
• Gastrocure V
• Gastrocure-v
• H-Done Maleate

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.