Dinoprost

Labour Inducer/Inhibitor · Prostaglandin

Indications

Therapeutic termination of pregnancy. Rarely used for induction of labour. See literature.

Dosage

Adults: Therapeutic termination of pregnancy: Intra-amniotically: Should not be given continuously for more than 2 days. For the termination of pregnancy during the sec trimester, 40 mg by slowly injecting 8 mL of a solution containing 5 mg/mL into the amniotic sac. A further dose of 10 to 40 mg after 24 hr may be given if the membranes are still intact. See literature. Children: Not recommended.

Adverse Effects

Nausea, vomiting, diarrhoea, blood loss, uterine infections, fever.

Risk Factor (Pregnancy/Lactation)

Contraindications: Pelvic infection; cervicitis, vaginal infections (extra-amniotic route); history of caesarean section or major uterine surgery. Precautions: Incomplete termination; history of asthma, glaucoma, raised intraocular pressure; high tone myometrial contractions.

Advice to Patient

Contact prescriber if there is nausea, vomiting, diarrhoea, stomach cramps/pain, continuing fever, chills, shivering, vaginal discharge with foul-odour, lower abdominal pain, unusual increased uterus bleeding.

Pharmacokinetics

Absorption: Slowly absorbed from the amniotic fluid into systemic circulation. Metabolism: Enzymatic dehydrogenation primarily in the maternal lungs and also in the liver. Half-life elimination: Amniotic fluid: 3-6 hrs. After IV adm: <1 min. Time to peak, plasma: 6-10 hrs after single 40 mg intra-amniotic dose. Excretion: Urine (Primarily). Faeces (5%).

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.