Dicyclomine and Simethicone

Antispasmodic & Anticholinergic · Antiflatulent/Antispasmodic

Indications

For the relief of flatulence, abdominal discomfort and infant colic (Wind) due to entrapped gas.

Dosage

Infants: 6 mth-4 yr, 5 mL before each feed, max four doses in 24 hr. Children: 4-12 yr, 5 to 10 mL four times daily. Adults: 10 mL three to four times daily.

Adverse Effects

Dry mouth, thirst and dizziness.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Caution advised or effect undetermined. Contraindications: Infants under 6 months. Precautions: Patients with actual or suspected glaucoma or prostatic hypertrophy. May exacerbate acid reflux in hiatus hernia.

Interactions

Amantadine, atenolol, digoxin, phenothiazines, tricyclic antidepressants.

Pharmacokinetics

DICYCLOMINE: Absorption: Rapid. 67% of an oral dose is absorbed from the GI tract. Bioavailability: For IM inj, it is greater than that of oral dose. Half-life elimination: For the first 9 hrs after a single dose: 1.8 hrs. Time to peak, plasma: 1-1.5 hr. Excretion: Urine (79.5%). Faeces (8.4%). SIMETHICONE: Absorption: Not absorbed into the blood stream. Metabolism: Not metabolized. Bioavailability: None. Excretion: Excreted unchanged in faeces.

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.