Deferiprone

Antidote · Oral iron chelator

Indications

Treatment of iron overload in patients with thalassaemia major for whom deferoxamine therapy is contraindicated or who present serious toxicity with deferoxamine therapy.

Dosage

Adults & Children: 25 mg/Kg of body wt three times daily. Max: 100 mg/Kg/day.

Adverse Effects

GI disturbances, joint pain. Rarely, agranulocytosis, neutropenia.

Risk Factor (Pregnancy/Lactation)

Contraindications: Neutropenia, agranulocytosis. Pregnancy & lactation. Precautions: Monitor neutrophil count, serum ferritin & Zn conc regularly. Discontinue if infection develops. Renal & hepatic impairment. Children.

Interactions

Aluminium containing antacids.

Pharmacokinetics

Absorption: Absorbed rapidly from the upper part of the GI tract. Metabolism: Hepatic. Half-life elimination: 1.9 hrs. Time to peak, serum: 1-2 hrs. Excretion: Urine (75%-90%).

Brands with this active ingredient

• Ferinil
• Ferriprox
• Hierro
• Kelfer
• Proxifer

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.