Darifenacin
Urinary Incontinence Products · Anticholinergic
Indications
Urinary incontinence, urgency and frequency.
Dosage
Adults: Initial 7.5 mg once daily. If response is not adequate after a minimum of 2 wk, dosage may be increased to 15 mg once daily. Daily dosage should not exceed 7.5 mg/day. Children: Not recommended.
Adverse Effects
Xerostomia, constipation, headache, dyspepsia, UTI, nausea, abdominal pain.
Risk Factor (Pregnancy/Lactation)
Lactation: Contraindicated or not recommended. Contraindications: Uncontrolled narrow angle glaucoma, urinary retention, paralytic ileus, GI or GU obstruction. Precautions: Angioedema involving the face, lips, tongue, operating machinery or driving, use caution in hot weather, caution in patients with bladder obstruction, prostatic hyperplasia, decreased GI motility, constipation, hiatus hernia, reflux oesophagitis, ulcerative colitis, Myasthaenia gravis, controlled narrow angle glaucoma, dementia, delirium.
Interactions
CYP3A4, CYP2D6, CYP2D6 substrates, aclidinium, conivaptan, ipratropium (oral inhalation), pimozide, thioridazine, tiotropium, abobotulinumtoxinA, anticholinergics, aripiprazole, cannabinoids, fesoterodine, lomitapide, mirabegron, nebivolol, onabotulinumtoxinA, potassium chloride, rimabotulinumtoxinB, thioridazine, topiramate, dasatinib, ivacaftor, mifepristone, pramlintide, propafenone, codeine, secretin, tamoxifen, tramadol, deferasirox, peginterferon alfa-2b, Tocilizumab.
Advice to Patient
Swallow with liquid. Do not chew, crush or break tablets. Avoid exercising in hot weather.
Brands with this active ingredient
Compiled by Healify Pharmacy from published drug references. How we compile it →
Always consult a pharmacist or doctor.