Dapagliflozin

Hypoglycaemic excluding Insulin · Reversible inhibitor of sodium-glucose co-transporter 2 (SGLT2)

Indications

Type II diabetes mellitus inadequately controlled by diet and exercise as monotherapy when metformin is not tolerated with other hypoglycaemic agent including insulin, when these alone are inadequate.

Dosage

Adults: 10 mg once daily. Combination sulphonylurea or insulin therapy, consider lower dose of sulphonylurea/insulin. Children: Not recommended.

Adverse Effects

Genital infection, UTI, dysuria, polyuria, back pain, dyslipidaemia, increased haematocrit, hypoglycaemia.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Moderate to severe renal impairment, volume depletion, diabetic ketoacidosis. Elderly = 75 years. Precautions: Severe hepatic impairment, increased haematocrit, volume depletion, heart failure, CVD, history of hypotension, pyelonephritis, urosepsis, glycosuria.

Interactions

Diuretics, pioglitazone, antihypertensive, ACE inhibitor, angiotensin II antagonist, DPP4 inhibitors, incretin mimetics.

Pharmacokinetics

Absorption: Rapid. Metabolism: Hepatic. Renal. Bioavailability: 78%. Half-life elimination: 13 hrs. Time to peak, plasma: Oral: 2-3 hrs. After high fat-meal: 2 hrs. Excretion: Urine (75%). Faeces (21%).

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.