Clotrimazole, Vaginal

Gynaecological Anti-infective · Imidazole antifungal

Indications

Candidal and mixed candidal/trichomonal vaginal infections.

Dosage

Cream: 1%: Adults: Insert contents of the applicator intravaginally at night for 7 consecutive nights. Cream/Gel 2%: Adults: Insert contents of the applicator intravaginally at night for 3 consecutive nights. Cream 10%: Adults: Insert contents of the applicator intravaginally at night as a single dose. Vaginal Tab: 100 mg: Adults: 1 tab inserted as single dose at night for 6 consecutive nights. Vaginal Tab: 500 mg: Adults: 1 tab inserted as single dose at night. Children: Below 12 yr, not recommended. Vaginal candidiasis in adolescents: Insert 5 gm of 10% vaginal cream, at night as a single dose; may be repeated once if necessary.

Adverse Effects

Local mild burning or irritation. Hypersensitivity reactions, erythema or irritation.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Not rated. Lactation: Caution advised or effect undetermined. Contraindications: Barrier contraceptives.

Interactions

Tacrolimus, sirolimus.

Advice to Patient

Before application, wash hands. Insert full applicator gently into vagina at bedtime and eject cream or insert tablet into vagina. Continue lying down for 30 min after administration. Notify prescriber about side effects such as vulvar itching or frequent urination or if condition remains same or if there is worsening of condition. Contact prescriber immediately if abdominal pain, fever or foul-smelling discharge occurs. Do not have intercourse during therapy.

Pharmacokinetics

Duration: Up to 3 days. Absorption: 3%-10%. Metabolism: Hepatic. Time to peak, plasma: 8-24 hrs. Excretion: Urine. Faeces.

Brands with this active ingredient

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.