Clobetasol, Topical

Corticosteroid, Plain · Corticosteroid

Indications

Psoriasis, intractable eczemas and other inflammatory dermatoses.

Dosage

Adults: Apply sparingly once or twice daily for max four wk, then review. Children: Same as adult but review weekly.

Adverse Effects

Burning, itching, irritation, erythema, dryness, folliculitis, hypertrichosis, pruritus, acneiform eruptions, hypo-pigmentation, peri-oral dermatitis, allergic contact dermatitis, numbness of fingers, stinging and cracking/tightening of skin, maceration of the skin, secondary infection, skin atrophy, striae, malaria, telangiectasia, cushingoid changes, adrenal suppression, local skin reactions, acne, folliculitis. Hypersensitivity reactions incl contact dermatitis (discontinue).

Risk Factor (Pregnancy/Lactation)

Contraindications: Monotherapy in primary bacterial infections such as impetigo, paronychia, erysipelas, cellulitis, angular cheilitis, erythrasma, treatment of rosacea, peri-oral dermatitis or acne; use on face, groin or axilla (very high or high potency agents). Untreated fungal or viral infections or parasitic infestations, use on burns, acne or rosacea, perioral dermatitis, widespread plaque psoriasis, perianal or genital pruritus, pruritus without inflammation. Precautions: Systemic effects usually results from use of more potent steroids, use over large surface area and the addition of occlusive dressings. If local irritation develops discontinue use. Skin atrophy may be clinically significant after prolong use of potent steroids or use on areas with higher percutaneous absorption. Do not use steroid as sole therapy in psoriasis. Do not use potent steroids to treat diaper…

Advice to Patient

Do not share your medicine with anyone. Contact prescriber if there is no improvement or worsening of condition.

Pharmacokinetics

Absorption: It ranges from about 1% in areas with a thick stratum corneum (such as the palms, soles, elbows, and knees) to as high as 36% in areas with a thin stratum corneum (face, eyelids, and genitals). Absorption increases in areas of skin damage, inflammation, or occlusion. Some systemic absorption of topical corticosteroids occurs, especially through the oral mucosa. Metabolism: After topical administration, drug is metabolized primarily in the skin. The small amount absorbed into systemic circulation is metabolized hepatically. Excretion: Urine (inactive metabolites). Faeces (small amounts of the metabolites).

Brands with this active ingredient

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.