Clobetasol Propionate and Salicylic Acid, Topical

Corticosteroid Combinations, Topical · Antiseptic/Corticosteroid

Indications

Psoriasis, intractable eczemas and other inflammatory dermatoses.

Dosage

Adults: Apply sparingly once or twice daily. May be used for max four wk, then review. Children: Same as adult but review weekly.

Advice to Patient

Wash and dry the skin before applying. Apply a thin film to cover affected areas and rub gently. Wash hands thoroughly after applying, unless hands are the area being treated. Cover affected area with dressing as recommended by prescriber. Occlusive dressings should be changed after 12 hours daily to reduce the risk of adverse effects. Do not apply for more than prescribed period of time. Avoid exposure to heat or smoking during and immediately after application. Avoid contact of medication with eyes, nose and mouth. In case of contact, wipe off the medication and rinse thoroughly with water.

Pharmacokinetics

CLOBETASOL: Absorption: It ranges from about 1% in areas with a thick stratum corneum (such as the palms, soles, elbows, and knees) to as high as 36% in areas with a thin stratum corneum (face, eyelids, and genitals). Absorption increases in areas of skin damage, inflammation, or occlusion. Some systemic absorption of topical corticosteroids occurs, especially through the oral mucosa. Metabolism: After topical administration, drug is metabolized primarily in the skin. The small amount absorbed into systemic circulation is metabolized hepatically. Excretion: Urine (inactive metabolites). Faeces (small amounts of the metabolites). SALICYLIC ACID: Absorption: Readily absorbed through the skin. Time to peak, serum: 5 hrs. Excretion: Urine.

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.