Clindamycin, Vaginal

Gynaecological Anti-infective · Lincosamide

Indications

Bacterial vaginosis.

Dosage

Cream: Adults: 1 applicatorful intravaginally at night for 7 days. Children: Not recommended. Ovule: Adults: Insert one ovule daily at night for 3 days. Children: Not recommended.

Adverse Effects

Diarrhoea or colitis (discontinue immediately). Cervicitis, vaginal candidiasis, vulvovaginitis, abdominal cramps, pruritus.

Risk Factor (Pregnancy/Lactation)

Pregnancy: No evidence of risk in humans. Lactation: Caution advised or effect undetermined. Contraindications: History of pseudomembranous colitis. Hepatic impairment. Lincomycin sensitivity. IBS or antibiotic-associated colitis. Precautions: Barrier contraceptives may be less effective.

Interactions

Neuromuscular blocking agents, erythromycin, vit K antagonists.

Advice to Patient

Before application, wash hands. Insert full applicator gently into vagina at bedtime and eject cream. After application, wash applicator with soap and water. Continue lying down for 30 min after administration. Contact prescriber if there is worsening of condition or nausea, abdominal cramps, dizziness or headache occurs or if condition remains same. Do not have intercourse for 7 days during therapy.

Pharmacokinetics

Absorption: Intravaginal cream: 5%. Pessary: 30%. Metabolism: Hepatic. Half-life elimination: 2-3 hrs. Time to peak, plasma: 4-24 hrs. Excretion: Urine (10%). Faeces (4%).

Unlicensed Use

Children: Bacterial vaginosis in adolescents: Insert 5 gm of 2% cream, at night for 3-7 nights.

Brands with this active ingredient

• Acnemycine
• C-Mycin
• Calidin-V
• Calinax
• Ceda-V 2%
• Climacin-V
• Climcin
• Climed-V
• Clinco
• Clinda-V
• Clindacef-V
• Clindamax-V
• Clindanor
• Clindex Vaginal
• Clinxer-V

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.