Clindamycin and Benzoyl Peroxide

Anti-acne Preps · Antibacterial-keratolytic/Lincosamide

Indications

Mild to moderate acne.

Dosage

Adults: Apply once daily in the evening after washing and drying the skin. Children: Not recommended.

Adverse Effects

Mild local irritation, headache. Reports of diarrhoea and colitis (discontinue immediately).

Risk Factor (Pregnancy/Lactation)

Contraindications: History of regional enteritis, ulcerative colitis or antibiotic associated colitis. History of lincomycin sensitivity. Precautions: Avoid eyes, mouth and mucous membranes. History of regional enteritis, ulcerative colitis or antibiotic-associated colitis. Atopic patients. Minimize exposure to UV light.

Advice to Patient

Wash affected area with mild, non-medicated cleanser, rinse with warm water and dry the skin before applying. Apply a thin film to cover affected areas and rub gently. Wash hands thoroughly after applying, unless hands are the area being treated. Apply it at the same time each day. Contact prescriber if there is no improvement or worsening of condition. Avoid medication contact with eyes, nose, mouth and broken skin. Do not change dosage or apply for more than prescribed period of time without consulting prescriber.

Pharmacokinetics

CLINDAMYCIN: Absorption: Minimal (4%-5%). Metabolism: Hepatic. Excretion: Urine. BENZOYL PEROXIDE: Absorption: Approx. 5% via skin. Gel has more penetration than cream. Metabolism: Converted to benzoic acid in skin. Excretion: Renal (urine).

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.