Clidinium and Chlordiazepoxide

Antispasmodic & Anticholinergic · Anticholinergic/Benzodiazepine

Indications

For the treatment of gastrointestinal manifestations of anxiety and tension.

Dosage

Adults: 1-2 dragees three to four times daily before meals and at bedtime. Elderly and frail patients, initially 1-2 dragees daily, increased gradually to the most effective well-tolerated dose. Children: Not recommended.

Adverse Effects

Constipation, transient bradycardia (followed by tachycardia, palpitation and arrhythmias), reduced bronchial secretions, urinary urgency and retention, dilatation of the pupils with loss of accommodation, photophobia, dry mouth, flushing and dryness of the skin. Side-effects that occur occasionally include confusion (particularly in the elderly), nausea, vomiting and giddiness. Very rarely, angle-closure glaucoma may occur.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Caution advised or effect undetermined. Contraindications: Antimuscarinics are contra-indicated in Myasthaenia gravis (but may be used to decrease muscarinic side-effects of anticholinesterases), paralytic ileus, pyloric stenosis, toxic megacolon and prostatic enlargement. Precautions: Antimuscarinics should be used with caution in Down's syndrome, in children and in the elderly; they should also be used with caution in gastro-esophageal reflux disease, diarrhoea, ulcerative colitis, autonomic neuropathy, acute myocardial infarction, hypertension, conditions characterised by tachycardia (including hyperthyroidism, cardiac insufficiency, cardiac surgery), pyrexia and in individuals susceptible to angle-closure glaucoma.

Interactions

Amantadine, atenolol, digoxin, phenothiazines, tricyclic antidepressants.

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.