Chorionic Gonadotrophin, Human (HCG)

Gonadotrophin including Other Ovulation Stimulant · Gonadotrophin

Indications

In the Males: Hypogonadotropic hypogonadism, delayed puberty associated with insufficient gonadotrophic pituitary function, cryptorchidism (not due to anatomical obstruction). In the Females: Ovulation induction due to anovulation or impaired follicle-ripening and in controlled hyperstimulation regimens to prepare the follicles for function.

Dosage

Males: Hypogonadotropic hypogonadism: Adults: 1000-2000 IU 2-3 times per wk. If the main complaint is sterility (deficient spermatogenesis) in combination with menotrophin (75 IU hFSH+75 IU hLH daily or 2-3 times a wk for at least 3 mth). Once achieved, the improvement in spermatogenesis may in some cases be maintained by hCG alone. Delayed puberty associated with insufficient gonadotrophic pituitary function: Adults: 1500 IU 2-3 times a wk for at least 6 mth. Females: Ovulation induction due to anovulation or impaired follicle-ripening: Adults: One inj of 5000-1000 IU to complete treatment with a menotrophin preparation. Ovulation induction in controlled hyperstimulation regimens to prepare the follicles for function: Adults: Up to three repeat injections of up to 5000 IU may be given within the following 9 days to prevent insufficiency of the corpus luteum. Children: Prepubertal…

Administration

IM administration only. Stability: Following reconstitution with the provided diluent, solutions are stable for 30-90 days, depending on the specific preparation, when stored at 2 degree C to 15 degree C.

Adverse Effects

Oedema, headache, tiredness, mood changes and sensitivity reactions.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Caution advised or effect undetermined. Precautions: Monitor hormone levels in anovulatory infertility. Asthma, epilepsy, migraine, cardiac or renal disorders.

Advice to Patient

If you are self-administering this medication, follow directions for reconstitution, injection and needle disposal. Administer exactly as directed. Contact prescriber if there is worsening of condition, swelling of legs/breasts/feet or if there is swelling/redness/pain at injection site.

Pharmacokinetics

Duration: IM: 36 hrs. Metabolism: Renal. Bioavailability: SC: 40%. Half-life elimination: Biphasic: First phase: 6-11 hrs. Terminal phase: 23-38 hrs. Time to peak: IM: 6 hrs. SC: 16-20 hrs. Excretion: Via urine within 24 hrs (10%-12% of dose).

Unlicensed Use

Children: Test of testicular function: IM. Short stimulation test: 1 mth-18 yr, 1500-2000 units once daily for 3 days. Prolonged stimulation test: 1 mth-18 yr, 1500-2000 units twice weekly for 3 wk.

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.