Chlorpropamide

Hypoglycaemic excluding Insulin · Sulphonylurea

Indications

Maturity-onset diabetes.

Dosage

Adults: Initial: 250 mg once daily with breakfast. Titrate: After 5-7 days, adjust by 50-125 mg daily every 3-5 days. Maint: 100-500 mg daily. Max: 750 mg daily. Children: Not recommended.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Risk cannot be ruled out. Lactation: Contraindicated or not recommended.

Advice to Patient

Take with meals. Contact prescriber if there is fever, sore throat, dark yellow or brown urine, yellow skin and eyes, bleeding or bruising. Monitor blood glucose level as instructed. Proper diet and regular exercise are also necessary along with medication to control blood glucose level. Do not skip meals or exercise too much. If there is confirmed or suspected hypoglycemia do not drive or operate machinery until blood glucose levels return to normal. Avoid exposure to sunlight.

Pharmacokinetics

Onset: 1 hr. Duration: At least 24 hrs. Absorption: Absorbed readily from the GI tract. Metabolism: Hepatic. Half-life elimination: 35 hrs. Time to peak, plasma: 2-4 hrs. Excretion: Urine (80%-90%).

Brands with this active ingredient

• Diab-Tus

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.