Chlorpheniramine, Inj/Oral

Antihistamine, Systemic · Antihistamine

Indications

Allergic conditions e.g. hay fever and other allergic rhinopathies, urticaria, pruritus, itching dermatoses, as adjuvant in acute and chronic eczema, contact dermatitis, drug eruptions.

Dosage

ORAL: Adults & Children: >12 yr: 4 mg every 4-6 hr or 8 mg every 8-12 hr or 12 mg every 12 hr; max: 24 mg/day. 6-11 yr: 2 mg every 4-6 hr; max: 12 mg/day. INJECTION: The dose repeated if required up to max 4 doses in 24 hr. By IM/IV inj over 1 min: Adults: 10 mg. Children: Under 6 mth, 250 mcg/kg; 6 mth-6 yr, 2.5 mg; 6-12 yr, 5 mg.

Administration

Chlorpheniramine 10 mg/mL may be administered by SC, IM, or IV injection slowly over a period of one min. Stability: Stored below 25 degree centigrade and protected from light.

Adverse Effects

Drowsiness, impaired reactions, dizziness, headache, somnolence, sedation, nausea, dry mouth, fatigue, attention disturbances, blurred vision.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Not rated. Lactation: Caution advised or effect undetermined. Precautions: Elderly. Epilepsy, raised IOP, BPH, severe hypertension, cardiovascular disease, renal or hepatic impairment, thyrotoxicosis, bronchitis, bronchiectasis, asthma, pyloroduodenal obstruction.

Interactions

Alcohol, CNS depressants, MAOIs, TCADs, phenytoin.

Advice to Patient

Take oral form with or without meals.

Pharmacokinetics

Duration: 4-6 hrs. Absorption: Slow from the GI tract. Rapid and extensive absorption in children. Metabolism: Hepatic. Bioavailability: Low (25%-50%). Half-life elimination: Wide interindividual variation (2%-43%). Shorter half-life in children. Time to peak, plasma: Oral: 2.5-6 hrs. Excretion: Urine (mainly). Faeces (trace amounts).

Brands with this active ingredient

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.