Cephradine

Cephalosporin · Cephalosporin

Indications

Infections of respiratory and gastro-intestinal tracts and of skin and soft tissues, bones and joints. Septicaemia, endocarditis. Prophylaxis in surgery. UTI.

Dosage

ORAL: Adults: 1-2 gm daily in 2 or 4 divided doses; max 4 gm daily. Children: 25-50 mg/kg daily in 2 or 4 divided doses. Continue in all cases for 48-72 hr after patient is asymptomatic. Lower Respiratory Infection: Pneumonia: Adults: 500 mg every 6 hr or 1 gm every 12 hr. Children: > 9 mth: 25-50 mg/kg/day given every 6 hr or every 12 hr (up to adult dose). Otitis Media: Children: > 9 mth: 75-100 mg/kg/day given every 6 hr or every 12 hr. Max: 4 gm/day. Upper Respiratory Infection: Tonsillitis/Pharyngitis: Adults: 250 mg every 6 hr or 500 mg every 12 hr. Children: > 9 mth: 25-50 mg/kg/day given every 6 hr or every 12 hr (up to adult dose). Skin Infection: Adults: 250 mg every 6 hr or 500 mg every 12 hr. Children: > 9 mth: 25-50 mg/kg/day given every 6 hr or every 12 hr (up to adult dose). Urinary Tract Infection: Adults: Uncomplicated: 500 mg every 12 hr. Serious (Prostatitis): 500 mg…

Administration

IM: Reconstitute with sterile water for injection 2 mL in 500 mg and 4 mL in 1 gm vial. The preparation is single use only. IV infusion: Reconstitute with sterile water for injection 5 mL in 500 mg vial shake to make solution. Transfer the entire contents to the IV infusion diluent. Protect from light. Compatibility: Dextrose 5% or 10 %, NaCl 0.9%. Stability: 2 hours at room temperature and 12 hours when stored in refrigerator.

Adverse Effects

Hypersensitivity reactions. GI upset, pseudomembranous colitis.

Risk Factor (Pregnancy/Lactation)

Pregnancy: No evidence of risk in humans. Lactation: Caution advised or effect undetermined. Precautions: Penicillin hypersensitivity, renal impairment.

Interactions

Probenecid, anticoagulants, aminoglycosides.

Advice to Patient

Take with or without meals. To reduce abdominal discomfort, take with meals. Take at regular intervals, as scheduled. Take missed dose as soon as possible unless it is almost time for the next dose. Do not double the dose. Shake oral suspension well before measuring and use a calibrated measuring device to ensure accurate dose. To improve flavour of oral suspension, refrigerate it but do not freeze. Contact prescriber if there are changes in urinary pattern, severe unrelieved diarrhoea, unusual bruising or bleeding, persistent abdominal pain, nausea or vomiting, vaginal itching, vaginal drainage, mouth sores, blood in stool or urine or if there is no improvement in condition. Do not take any new medication especially any OTC antidiarrhoeal without consulting prescriber. Complete full course of therapy even if you feel better. Take sufficient amount of fluids (2-3 litres per day) to…

Pharmacokinetics

Absorption: Oral: Rapidly and almost completely absorbed from the GI tract. Absorption is delayed by the presence of food. Metabolism: Not metabolized. Half-life elimination: 1 hr. Prolonged in patients with renal impairment. Time to peak, plasma: Oral: 1 hr. IM: 1-2 hrs. Excretion: Urine (IM: 60%-80%. Oral: >90%).

Brands with this active ingredient

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Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.