Ceftazidime

Cephalosporin · Cephalosporin

Indications

Infections of the respiratory tract, ENT, skin and soft tissues, bone and joints, biliary and Gl tract. UTI. Septicaemia, meningitis. Infections in immunocompromised patients.

Dosage

Adults: 1-6 gm/day in 2 or 3 divided doses by IV or IM inj. Children: Above 2 mth, 30-100 mg/kg/day in 2 or 3 divided doses; under 2 mth, 25-60 mg/kg/day in 2 divided doses. Bone Infection: IV: Adults: 2 gm every 12 hr. Children: 1 mth-12 yr: 30-50 mg/kg every 8 hr, up to 6 gm/day. 0-4 wk: 30 mg/kg every 12 hr. Meningitis: IV: Adults: 2 gm every 8 hr. Children: 1 mth-12 yr: 30-50 mg/kg every 8 hr, up to 6 gm/day. 0-4 wk: 30 mg/kg every 12 hr. Septicaemia: IV: Adults: 2 gm every 8 hr. Children: 1 mth-12 yr: 30-50 mg/kg every 8 hr, up to 6 gm/day. 0-4 wk: 30 mg/kg every 12 hr. Empiric therapy in immuno-compromised patients: Adults: IV: 2 gm every 8 hrs.

Administration

IM: Inject deep IM into large mass muscle. IV: Ceftazidime can be administered IVP over 3-5 min or IV intermittent infusion over 15-30 min; final concentration for IV administration should not exceed 100 mg/ mL. Rotate IV sites every 72 hours. Assess for phlebitis and extravasation. Reconstitution: IV: For IV bolus, reconstitute 1-2 gm with 10 mL SWFI, D5W, or NaCl. Shake to dissolve. For intermittent infusion, further dilute in 50-100 mL D5W or NS. IM: Reconstitute each gm with 3 mL SWFI or bacteriostatic water for injection. Compatibility: D5NS, D5W, NS, SWFI. Stability: For reconstituted solution and IV infusion in NS or D5W solution is stable for 24 hours at room temperature, 10 days when refrigerated, or 12 weeks when frozen.

Adverse Effects

Pain at inj site, hypersensitivity reactions. Gl disturbances, candidiasis, eosinophilia, neutropenia, leucopenia, thrombocytopenia, rise in liver enzymes and blood urea. Positive Coomb's test, phlebitis or thrombophlebitis, thrombocytosis, pseudomembranous colitis, haemolytic anaemia.

Risk Factor (Pregnancy/Lactation)

Pregnancy: No evidence of risk in humans. Lactation: Contraindicated or not recommended. Contraindications: Severe hypersensitivity to other B-lactams. Precautions: Penicillin sensitivity. Impaired renal function.

Interactions

Aminoglycosides, loop diuretics, chloramphenicol.

Advice to Patient

Contact prescriber if there is burning/swelling/redness/pain at injection or infusion site or if there is rash, hives, itching, difficulty in breathing or swallowing, severe unrelieved diarrhoea, vaginal drainage or itching, mouth sores, pus/blood/mucus in stools, unusual chills or fever, easy bruising or bleeding. Watery or bloody stools can occur 2 or more months after therapy and can be serious, requiring immediate treatment. Take sufficient amount of fluids (2-3 litres per day) to maintain hydration, unless restricted by the prescriber.

Pharmacokinetics

Half-life elimination: 1-2 hrs, prolonged with renal impairment. Time to peak, serum: IM: Approx. 1 hr. Excretion: Urine.

Brands with this active ingredient

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.