Cefprozil
Cephalosporin · Cephalosporin
Indications
Upper respiratory tract infections, otitis media, acute exacerbation of chronic bronchitis, skin and skin structure infections.
Dosage
Lower Respiratory Infection: Adults & Children: 13 yr and above: 500 mg every 12 hr for 10 days. Otitis Media: Children: 6 mth-12 yr: 15 mg/kg every 12 hr for 10 days. Upper Respiratory Infection: Pharyngitis/Tonsillitis: Adults & Children: 13 yr and above: 500 mg once daily for 10 days. 2-12 yr: 7.5 mg/kg every 12 hr for 10 days. Max: Adult dose. Sinusitis: Adults & Children: 13 yr and above: 250-500 mg every 12 hr for 10 days. 6 mth-12 yr: 7.5-15 mg/kg every 12 hr for 10 days. Max: Adult dose. Skin Infection: Adults & Children: 13 yr and above: 250-500 mg every 12 hr or 500 mg every 24 hr for 10 days. 2-12 yr age: 20 mg/kg every 24 hr for 10 days.
Adverse Effects
Gl upset, dizziness, nappy rash, superinfection, genital pruritus, vaginitis. Raised AST, ALT. Eosinophilia.
Risk Factor (Pregnancy/Lactation)
Pregnancy: No evidence of risk in humans. Lactation: Contraindicated or not recommended. Precautions: Severe renal impairment. History of GI disease particularly colitis; discontinue with signs of diarrhoea. Phenylketonuria. Hypersensitivity to penicillins.
Interactions
Glucose tests, probenecid, furosemide, aminoglycosides.
Advice to Patient
Take at regular intervals, as scheduled. Shake oral suspension well before measuring and use a calibrated measuring device to ensure accurate dose. To improve flavour of oral suspension, refrigerate it but do not freeze. Contact prescriber if there is severe unrelieved diarrhoea, changes in urinary pattern, vaginal itching, vaginal drainage, mouth sores, blood in urine, unusual chills or fever, rash. Watery or bloody stools can occur 2 or more months after therapy and can be serious, requiring immediate treatment. Complete full course of therapy even if you feel better. Take sufficient amount of fluids (2-3 litres per day) to maintain hydration, unless restricted by the prescriber.
Pharmacokinetics
Absorption: Well absorbed (95%). Bioavailability: 95%. Half-life elimination: Infants and Children 6 mth-12 yrs: 1.5 hrs. Adults: Normal hepatic and renal function: 1.3 hrs. Renal impairment: 5.2 hrs. Renal failure: 5.9 hrs. Hepatic impairment: 2 hrs. Time to peak, serum: Fasting: 1.5 hrs. Excretion: Urine.
Brands with this active ingredient
Compiled by Healify Pharmacy from published drug references. How we compile it →
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