Cefoperazone and Sulbactam

Cephalosporin · Beta-lactamase inhibitor/Cephalosporin

Indications

Respiratory tract, UTI, skin & soft tissue, bone & joint, intra-abdominal infections, peritonitis, cholecystitis, septicaemia, meningitis.

Dosage

Adults: 2-4 gm/day IV in equally divided doses every 12 hr, may be increased up to max 8 gm/day (equiv to cefoperazone 4 gm/day) in severe infections. Children: 40-80 mg/kg/day in 2-4 equally divided doses, may be increased up to max 180 mg/kg/day in severe infections. Newborn infants to 1 wk: 40-80 mg/kg/day every 12 hr. Max sulbactam dose in children 80 mg/kg/day. For cefoperazone dose >80 mg/kg/day, given cefoperazone separately.

Adverse Effects

Diarrhoea, nausea & vomiting, maculopapular rash & urticaria, haematological changes, headache, fever, inj pain, chills, increase in liver enzymes.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Risk cannot be ruled out. Lactation: Caution advised or effect undetermined. Contraindications: History of allergies to penicillins, cephalosporins or sulbactam.

Interactions

Physical incompatibility with aminoglycoside, doxycycline, meclofenoxate, ajmaline, hydroxyzine, procainamide, aminophylline, prochlorperazine, cytochrome C, pentazocine, aprotinin.

Advice to Patient

Avoid alcohol during treatment.

Pharmacokinetics

CEFOPERAZONE: Metabolism: Not metabolized significantly. Half-life elimination: 2 hrs. Prolonged in neonates and in patients with hepatic or biliary-tract disease. Time to peak, plasma: 1-2 hrs. Excretion: Faeces (mainly). Urine (30%). SULBACTAM: Half-life elimination: Children 1-12 yrs (normal renal function): Mean range: Approx. 0.7-0.9 hrs. Adults (normal renal function): 1-1.3 hrs. Excretion: Urine (approx. 75%-85%).

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.