Bromazepam
Tranquilizer, Sedative/Hypnotic · Benzodiazepine
Indications
Short-term treatment of anxiety that is severe or disabling occurring alone or with insomnia.
Dosage
Adults: Elderly, 1.5-9 mg daily; others, 3-18 mg daily. Both in divided doses. Children: Not recommended.
Adverse Effects
Drowsiness and light headedness, which may continue into the following day. Muscle weakness, ataxia, confusion, vertigo, GI upset, hypotension, visual disturbance, rash, impaired alertness and dexterity, headache, urinary retention, changes in libido, Rarely blood disorder, jaundice, respiratory depression, abnormal psychological reactions. Paradoxical reactions, anterograde amnesia. Dependence. Injection: Rarely, thrombophlebitis.
Risk Factor (Pregnancy/Lactation)
Pregnancy: Not rated. Lactation: Caution advised or effect undetermined. Contraindications: Acute pulmonary insufficiency, respiratory depression, sleep apnoea, phobic or obsessional state, chronic psychosis, unstable Myasthaenia gravis. Severe hepatic impairment. As monotherapy to treat depression or anxiety associated with depression. Precautions: Chronic pulmonary insufficiency, Myasthaenia gravis, renal impairment, mild to moderate hepatic impairment, history of drugs or alcohol abuse, personality disorders, Elderly, avoid long-term use. Withdraw gradually.
Interactions
Alcohol, CNS depressants, anticonvulsants, CYP3A4 inhibitors or inducers (e.g. cimetidine, rifampicin).
Advice to Patient
Take with or without meals. Contact prescriber if there is poor concentration, changes in weight, changes in sleep pattern, decreased interest in activities. Avoid alcohol during therapy.
Pharmacokinetics
Absorption: Fasting state: Almost completely absorbed. Metabolism: Hepatic. Bioavailability: Oral: 84%. Half-life elimination: 17 hrs. (Range 11-22 hrs). Time to peak, plasma: 0.5-4 hrs. Excretion: Urine (69%; as metabolites).
Brands with this active ingredient
Compiled by Healify Pharmacy from published drug references. How we compile it →
Always consult a pharmacist or doctor.