Betamethasone Valerate and Gentamicin, Topical

Corticosteroid Combinations, Topical · Aminoglycoside/Corticosteroid

Indications

Infected inflammatory and allergic skin conditions.

Dosage

Adults & Children: Apply three or four times daily.

Advice to Patient

Apply a thin film to cover affected areas and rub gently. If a dose is missed, apply it as soon as you remember, unless it is almost time for the next dose. Do not apply double dose. Do not cover the area under treatment unless recommended by prescriber.

Pharmacokinetics

BETAMETHASONE VALERATE: Absorption: It ranges from about 1% in areas with a thick stratum corneum to as high as 36% in areas with a thin stratum corneum. Absorption increases in areas of skin damage, inflammation, or occlusion. Some systemic absorption of topical steroids occurs. Metabolism: After topical administration, drug is metabolized primarily in skin. The small amount absorbed into systemic circulation is metabolized hepatically. Excretion: Renal (inactive metabolites). Faeces (small amounts of metabolites). GENTAMICIN: Absorption: Readily absorbed from large burnt, denuded or granulating areas but not through intact skin. Faster and greater absorption with the cream compared to the ointment. Metabolism: Not metabolized. Half-life elimination: Adults: 2-3 hrs. Severe renal impairment: 24-60 hrs. Excretion: Urine.

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.