Betamethasone Dipropionate and Gentamicin, Topical

Corticosteroid Combinations, Topical · Aminoglycoside/Corticosteroid

Indications

Infected inflammatory and allergic skin conditions.

Dosage

Adults & Children: Apply three or four times daily.

Advice to Patient

Do not use occlusive dressing. Do not stop applying medication abruptly, gradually lower the dose and then stop.

Pharmacokinetics

BETAMETHASONE DIPROPIONATE: Absorption: It ranges from about 1% in areas with a thick stratum corneum to as high as 36% in areas with a thin stratum corneum. Absorption increases in areas of skin damage, inflammation, or occlusion. Some systemic absorption of topical steroids occurs. Metabolism: After topical administration, drug is metabolized primarily in skin. The small amount absorbed into systemic circulation is metabolized hepatically. Excretion: Renal (inactive metabolites). Faeces (small amounts of metabolites). GENTAMICIN: Absorption: Readily absorbed from large burnt, denuded or granulating areas but not through intact skin. Faster and greater absorption with the cream compared to the ointment. Metabolism: Not metabolized. Half-life elimination: Adults: 2-3 hrs. Severe renal impairment: 24-60 hrs. Excretion: Urine.

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.