Betamethasone Dipropionate and Clotrimazole, Topical

Corticosteroid Combinations, Topical · Corticosteroid/Imidazole antifungal

Indications

Inflammation and infection of skin involving fungi.

Dosage

Adults & Children: Apply twice daily.

Adverse Effects

Cushingoid changes, adrenal suppression, local skin reactions, acne, atrophy, striae, telangiectasia, mild pigmentation, hypertrichosis, pruritus, folliculitis. Hypersensitivity reactions incl contact dermatitis (discontinue).

Risk Factor (Pregnancy/Lactation)

Contraindications: Untreated bacterial, fungal or viral infections or parasitic infestations, use on burns, acne or rosacea, perioral dermatitis, widespread plaque psoriasis, perianal or genital pruritus, pruritus without inflammation. Precautions: Do not use potent steroids to treat diaper dermatoses in infants. Avoid extensive or prolonged use (limit to max 7 days in children). If using potent steroids in children or on face, limit to 5 days and avoid occlusion. Avoid mucous membranes and eye area. Broken, inflamed or occluded skin, psoriasis, dermatitis around chronic leg ulcers. Risk of visual disturbances. Elderly.

Advice to Patient

For topical use only. Contact prescriber if condition remains same or if there are any side effects. Avoid contact with eyes and mouth. Avoid using for long period of time. Avoid using under diapers or dressings. Shake lotion well before use.

Pharmacokinetics

BETAMETHASONE DIPROPIONATE: Absorption: It ranges from about 1% in areas with a thick stratum corneum to as high as 36% in areas with a thin stratum corneum. Absorption increases in areas of skin damage, inflammation, or occlusion. Some systemic absorption of topical steroids occurs. Metabolism: After topical administration, drug is metabolized primarily in skin. The small amount absorbed into systemic circulation is metabolized hepatically. Excretion: Renal (inactive metabolites). Faeces (small amounts of metabolites). CLOTRIMAZOLE: Absorption: Negligible systemic absorption. Metabolism: Hepatic. Excretion: Urine. Faeces.

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.