Beraprost

Anticoagulant/Antiplatelet · Antiplatelet

Indications

Improvement of ulcers, pain and feeling of coldness associated with chronic arterial occlusion. Primary pulmonary hypertension.

Dosage

Chronic arterial occlusion: Adults: 40 mcg three times daily. Primary Pulmonary hypertension: Adults: Start from a lower dose. Usual dose: 1 mcg/kg/day up to 20 mcg three times daily. Reduce dose to 0.5 mcg/kg/day or 20-40 mcg daily in 2-3 divided doses if adverse reaction occur, or discontinue if needed. Gradually increase dose if needed up to max 180 mcg in three or four divided doses. Children: Not recommended.

Adverse Effects

Headache, flushing, nausea, diarrhoea, bleeding tendency, dizziness, increased liver enzyme, bilirubin and triglyceride concentrations.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Contraindications: Patients with haemorrhage. Precautions: Patients on anticoagulants, antiplatelet, or fibrinolytic agents. Menstruating women, patients with bleeding tendency or diathesis. May enhance bleeding tendency.

Interactions

Anticoagulants, antiplatelet, or fibrinolytic agents or any product that intensifies bleeding tendency. Prostaglandin I2 preparations.

Advice to Patient

Take after meals.

Pharmacokinetics

Bioavailability: Oral: 50%-70%. Half-life elimination: 35-40 mins. Excretion: Urine. Faeces.

Brands with this active ingredient

• Benprost

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.