Bempedoic Acid

Hypolipidaemic/Anti-atheroma · Adenosine triphosphate citrate lyase (ACL) inhibitor

Indications

As an adjunct to diet and maximally tolerated statin therapy for the treatment of heterozygous familial hypercholesterolaemia or established atherosclerotic cardiovascular disease who require additional lowering of LDL-C.

Dosage

Adults: 180 mg orally once daily. Children: Not recommended.

Adverse Effects

Upper respiratory tract infection, muscle spasms, hyperuricaemia, back pain, abdominal pain or discomfort, bronchitis, pain in extremity, anaemia and elevated liver enzymes.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: History of tendon disorders. Tendon rupture. Precautions: Assess uric acid levels periodically. Discontinue at the first sign of tendon rupture.

Interactions

Simvastatin, pravastatin (avoid).

Advice to Patient

Rest at the first sign of tendinitis or tendon rupture and immediately inform prescriber. Take with or without meals.

Pharmacokinetics

Time to peak: 3.5 hrs. Metabolism: Hepatic. Excretion: Urine (70%). Faeces (30%).

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.