Aztreonam

Other Anti-infective Preps · Monobactam

Indications

Treatment of the following infection caused by susceptible gram-negative microorganisms: UTIs, Lower RTIs, septicaemia, skin and skin-structure infections, intra-abdominal infections, gynaecologic infections.

Dosage

Adults: IV/IM: UTI: 500 mg or 1 gm as required every 8-12 hrs. Moderately severe systemic infections: 1 gm-2 gm as required every 8-12 hrs. Severe systemic or life-threatening infections: 2 gm every 6-8 hrs. Max: 8 gm/day. Children =9 months: IV: Mild to moderate infections: 30 mg/kg every 8 hrs. Moderate to severe infections: 30 mg/kg every 6-8 hrs. Max: 120 mg/kg/day. <9 months: Not recommended.

Administration

Adm via IV or IM route. Reconstitution: IV: Bolus: Constitute with 6-10 mL SWFI. Infusion: Initially constitute each gram of aztreonam with at least 3 Ml SWFI. Further dilution may be obtained with one of the compatible IV infusion solns. IM: Constitute with at least 3 mL of an appropriate diluent per gram aztreonam. Compatibility: IV infusion: Normosol-M and D5W, Mannitol inj 5% or 10%, Lactated ringer’s and D5W, Plasma-lyte M and D5W, 10% Travert inj, 10% Travert and Electrolyte no. 1 inj., 10% Travert and Electrolyte no. 2 inj, 10% Travert and Electrolyte no. 3 inj. IM: SWFI, SBWFI (with benzyl alcohol or with methyl- and propylparabens), NaCl inj 0.9%, Bacteriostatic NaCl inj (with benzyl alcohol). Stability: Reconstituted sol (conc not exceeding 2% w/v) for IV inf and IM inj must be used within 48 hrs if kept at controlled room temp (20-25°C) or within 7 days if refrigerated…

Adverse Effects

Phlebitis/thrombophlebitis, diarrhoea, nausea, vomiting, abdominal cramps, rash, pancytopaenia, neutropaenia, thrombocytopaenia, anaemia, eosinophilia, leukocytosis, thrombocytosis.

Risk Factor (Pregnancy/Lactation)

Pregnancy: No evidence of risk in humans. Lactation: Contraindicated or not recommended. Precautions: Renal and hepatic impairment. Elderly.

Advice to Patient

Do not drive or operate machinery until you know how the medication affects you. Limit alcohol consumption. Report watery or bloody stools, with or without stomach cramps, that does not stop, even up to two months after treatment. (Do not take anti-diarrhoeal medicine without consulting prescriber first). Regular lab tests may be required to check your body's response to the medication, especially if you have kidney or liver disease.

Pharmacokinetics

Metabolism: Minimal metabolism (6-16% of the dose via hydrolysis of its beta-lactam bond). Half-life elimination: 1.5-2 hrs. Excretion: Urine.

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.