Aspirin and Vonoprazan

Anticoagulant/Antiplatelet · Potassium-competitive acid blocker/Salicylate

Indications

Risk reduction of formation of thrombosis/embolism due to the following disease or after operation (limited to the patients with history of gastric ulcer or duodenal ulcer): (1) Angina (chronic stable angina, unstable angina), myocardial infarction, ischemic cerebrovascular disease ((transient ischemic attack (TIA), cerebral infarction)). (2) After coronary artery bypass graft (CABG) or percutaneous transluminal coronary recanalization (PTCA).

Dosage

Adults: 1 tab once daily. Children: Not recommended.

Adverse Effects

Constipation, diarrhoea, abdominal bloating, nausea, abdominal pain, esophagitis, gastric distress, itch, anaemia, reduced BP, oedema.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Positive evidence of risk: Use only when no safer alternative exists for a serious problem. Lactation: Contraindicated or not recommended. Contraindications: Severe renal or hepatic impairment. Previous or active peptic ulceration, haemophilia and other bleeding disorders. Precautions: Endoscopy is conducted during long-term adm. Elderly. History of bronchospasm, asthma, dehydration, uncontrolled hypertension, G6PD deficiency. Mild to moderate renal impairment.

Advice to Patient

Swallow whole tab. Do not break, crush or chew tab. Avoid alcohol. Report if any of the following symptoms occur: General malaise, fever, shortness of breath, nose bleed/subcutaneous bleeding, skin/eyes/mouth rash, redness, skin falling off, generalized rash, headache, nausea/vomiting, consciousness disorder, motor paralysis, phlegm with blood, melena, black stool, vision disorder, whistling breath, yellowing of the skin and the white of the eyes, loss of appetite.

Pharmacokinetics

ASPIRIN: Onset: Immediate release: Platelet inhibition: Within 1 hr (nonenteric-coated). Onset of enteric-coated aspirin expected to be delayed. Duration: Immediate release: 4-6 hrs. Absorption: Immediate release: Rapidly absorbed in stomach and upper intestine. Extended release capsule: Rate of absorption depends upon food, alcohol and gastric pH. Metabolism: Via esterases in GI mucosa, RBCs, synovial fluid and blood. Salicylate: Via hepatic conjugation. Bioavailability: Immediate release: 50%-75%. Half-life elimination: Parent drug: Plasma conc: 15-20 min. Salicylates (dose dependant): 3 hrs at lower doses (300-600 mg), 5-6 hrs (after 1 gm), 10 hrs with higher doses). Time to peak, serum: Immediate release: Approx 1-2 hrs (nonenteric-coated), 3-4 hrs (enteric-coated). Extended release capsule: Approx. 2 hrs. Excretion: Urine. VONOPRAZAN: Absorption: Rapidly absorbed from the GI…

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.