Aspirin and Paracetamol

Non-narcotic Analgesic · Para-aminophenol derivative/Salicylate

Indications

Pain, fever.

Dosage

Adults: 2 tab 3-4 times daily. Children: Not recommended.

Adverse Effects

ASPIRIN: Bronchospasm, GI upset, allergic reactions, GI and other haemorrhage. Tinnitus, vertigo, confusion, increased bleeding. PARACETAMOL: Cyanosis, skin eruptions, hypoglycaemia, CNS stimulations. Inj: Hypotension, flushing and tachycardia.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Risk cannot be ruled out. Lactation: Caution advised or effect undetermined. Contraindications: ASPIRIN: Previous or active peptic ulceration, haemophilia and other bleeding disorders. Severe renal or hepatic impairment Children under 16 years unless specifically indicated (e.g. for Kawasaki's disease). Precautions: ASPIRIN: Aspirin/anti-inflammatory induced allergies, history of bronchospasm, asthma, uncontrolled hypertension, mild to moderate renal function, renal or hepatic impairment, dehydration, G6PD deficiency. Not recommended for treatment of gout. Elderly; avoid continuous prolonged use. PARACETAMOL: Impaired hepatic or renal function, alcoholism. Chronic malnutrition, dehydration, wt <50 Kg, G6PD deficiency, haemolytic anaemia. Risk of serious skin reactions (discontinue).

Interactions

ASPIRIN: Oral anticoagulants, heparin, antiplatelet agents, fibrinolytics, NSAIDs, uricosuric agents, methotrexate, SSRls, venlafaxine, corticosteroids, acetazolamide. PARACETAMOL: Drugs which delay gastric emptying (e.g. anticholinergics, narcotics). Carbamazepine, metoclopramide, domperidone, colestyramine, oral anticoagulants, busulfan, hepatotoxic drugs, zidovudine, alcohol.

Advice to Patient

Take with or without meals. Do not lie down for 30 minutes after taking medication. Do not take more than 10 days for pain and more than 3 days for fever. Do not take medication for atleast 7 days after surgery. Contact prescriber if there is redness/swelling, dark stools, diarrhoea, vomit that has blood and look like coffee grounds, unusual weight gain, irritation in eyes, sores in mouth/throat/nose/eyes, ringing in ears, severe stomach pain, unusual fatigue, yellowing of the skin or eyes. Avoid alcohol and smoking during therapy. Avoid doing tasks that may cause bruising or injury.

Pharmacokinetics

ASPIRIN: Onset: Immediate release: Platelet inhibition: Within 1 hr (nonenteric-coated). Onset of enteric-coated aspirin expected to be delayed. Duration: Immediate release: 4-6 hrs. Absorption: Immediate release: Rapidly absorbed in stomach and upper intestine. Extended release capsule: Rate of absorption depends upon food, alcohol and gastric pH. Metabolism: Via esterases in GI mucosa, RBCs, synovial fluid and blood. Salicylate: Via hepatic conjugation. Bioavailability: Immediate release: 50%-75%. Half-life elimination: Parent drug: Plasma conc: 15-20 min. Salicylates (dose dependant): 3 hrs at lower doses (300-600 mg), 5-6 hrs (after 1 gm), 10 hrs with higher doses). Time to peak, serum: Immediate release: Approx 1-2 hrs (nonenteric-coated), 3-4 hrs (enteric-coated). Extended release capsule: Approx. 2 hrs. Excretion: Urine. PARACETAMOL: Onset of action: Oral: <1 hr. IV: Analgesia:…

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.