Aprocitentan

Antihypertensive · Endothelin receptor antagonist

Indications

Hypertension, used in combination with other antihypertensive drugs.

Dosage

Adults: 12.5 mg once daily. Children: Not recommended.

Adverse Effects

Oedema/fluid retention, anaemia, hepatotoxicity, decreased sperm count.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Severe renal impairment (eGFR <15 mL/min). Moderate and severe hepatic impairment. Precautions: Hepatic impairment.

Advice to Patient

Take with or without meals. Swallow tabs whole. Patients of reproductive potential must use effective contraception before starting treatment, during treatment and for 1 month after stopping treatment.

Pharmacokinetics

Metabolism: Hepatic and non-enzymatic hydrolysis. Half-life elimination: Approx. 41 hrs. Time to peak, plasma: 4-5 hrs. Excretion: Urine (52%). Faeces (25%).

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.