Antihemophilic Factor

Antihaemorrhagic/Antihemophilic · Antihaemophilic

Indications

Classical haemophilia (haemophilia A) in which there is demonstrated deficiency of activity of plasma clotting factor, Factor VIII. Provides a means of temporarily replacing the missing clotting factor in order to correct or prevent bleeding episodes, or in order to perform emergency and selective surgery on haemophiliacs.

Dosage

See literature.

Administration

IV: Total dose may be administered over 5-10 min (maximum 10 mL/min). Adapt based on patient response. Stability: Store under refrigeration 2°C-8°C (36°F-46°F). Avoid freezing. Use within 3 hours of reconstitution. Gently agitate or rotate vial after adding diluents, do not shake vigorously. Do not refrigerate after reconstitution, precipitation may occur. May be stored at room temperature for = 2 months. If refrigerated, the dried concentrate and diluent should be warmed to room temperature before reconstitution.

Adverse Effects

See literature.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Positive evidence of risk: Use only when no safer alternative exists for a serious problem. Lactation: Caution advised or effect undetermined. Contraindications: See literature. Precautions: In persons with previous transfusions of blood and plasma products, possibly by contacting viral hepatitis must be considered.

Interactions

See literature.

Advice to Patient

To be administered via intravenous route only. Contact prescriber if there is sudden-onset headache, rashes, chest pain, back pain, wheezing or respiratory difficulties, hives, itching, low-grade fever, stomach pain, nausea or vomiting. Patients must wear or carry identification card indicating haemophilic condition.

Pharmacokinetics

Half-life elimination: 14.8 hrs. Excretion: Rapidly eliminated primarily through the reticuloendothelial system.

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.