Adenosine
Cardiac Therapy · Anti-arrhythmic
Indications
Rapid conversion to a normal sinus rhythm of paroxysmal supraventricular tachycardias, including those associated with accessory by-pass tracts (Wolff-Parkinson-White Syndrome). Diagnostic: Aid to diagnosis of broad or narrow complex supraventricular tachycardias. Sensitization of intra-cavitary electrophysiological investigations.
Dosage
Adults: Initial dose: 3 mg given as a rapid IV bolus (over 2 seconds). Second dose: If the first dose does not result in elimination of the supraventricular tachycardia within 1 to 2 minutes, 6 mg should be given also as a rapid intravenous bolus. Third dose: If the second dose does not result in elimination of the supraventricular tachycardia within 1 to 2 minutes 12mg should be given also as a rapid intravenous bolus. Higher doses are not recommended. Children: Treatment of paroxysmal supraventricular tachycardia: First bolus of 0.1 mg/kg body weight (maximum dose of 6mg). Increments of 0.1 mg/kg body weight as needed to achieve termination of supraventricular tachycardia; max dose: 12 mg.
Administration
Administered via rapid intravenous (IV) bolus injection into a vein or into an IV line. If given into an IV line it should be injected through as proximally as possible and followed by a rapid saline flush. If administered through a peripheral vein, a large bore cannula should be used.
Adverse Effects
Flushing, chest discomfort, shortness of breath, throat/neck/jaw discomfort, abdominal pain, dizziness, nausea, headache, stomach upset, weakness, hypotension, nervousness, irregular heartbeat, heart attack and ventricular arrhythmias.
Risk Factor (Pregnancy/Lactation)
Pregnancy: Not rated. Lactation: Contraindicated or not recommended. Contraindications: Sick sinus syndrome, second or third degree Atrioventricular (AV) block (except in patients with a functioning artificial pacemaker), chronic obstructive lung disease with evidence of bronchospasm (e.g. asthma bronchiole), long QT syndrome, severe hypotension, decompensated states of heart failure. Precautions: The occurrence of angina, severe bradycardia, severe hypotension, respiratory failure (potentially fatal), or asystole/cardiac arrest (potentially fatal), should lead to immediate discontinuation of administration. Adenosine may trigger convulsions in patients who are susceptible to convulsions. In patients with history of convulsions/seizures, the administration of adenosine should be carefully monitored. Because of the possible risk of torsades de pointes, adenosine injection should be used…
Interactions
Dipyridamole, aminophylline, theophylline and other xanthines.
Brands with this active ingredient
Compiled by Healify Pharmacy from published drug references. How we compile it →
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