Adapalene, Topical

Anti-acne Preps · Retinoid

Indications

Mild to moderate acne where comedones, papules and pustules predominate.

Dosage

Adults: Apply thin film once daily at bedtime after washing and drying the affected area. Reassess after 3 mth. Children: Not recommended.

Adverse Effects

Local skin irritation; reduce application or withdraw if severe. Dry skin.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Risk cannot be ruled out. Lactation: Caution advised or effect undetermined. Contraindications: Severe acne, broken skin, eczema. Precautions: Avoid eyes, lips, angles of nose, mucous membranes, excessive exposure to sunlight. Pregnancy, adequate contraception must be used.

Interactions

Retinoids.

Advice to Patient

For external use only. Wear gloves and apply a thin layer of medication thoroughly to clean and dry skin at night. Contact prescriber if there is worsening of condition, persistent skin redness, burning sensation, dryness or peeling. Avoid contact with areas around eyes and mouth. Avoid using occlusive dressing unless recommended by prescriber. Results may appear in 8-12 weeks.

Pharmacokinetics

Onset: Optimal response is seen after 8-12 wks. Absorption: Low absorption through skin. Metabolism: Via O-demethylation, hydroxylation and conjugation. Excretion: Biliary (Faeces).

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.