Abrocitinib

Other Dermatologicals · Janus kinase (JAK) inhibitors

Indications

Treatment of adults with refractory, moderate-to-severe atopic dermatitis whose disease is not adequately controlled with other systemic drug products, including biologics, or when use of those therapies is inadvisable.

Dosage

ORAL: Adults: 100 mg once daily. For those patients who are not responding to 100 mg once daily, recommended dosage is 200 mg once daily. Discontinue therapy if inadequate response is seen after dosage increase to 200 mg once daily. It can be used with or without topical corticosteroids. Children: Not recommended.

Adverse Effects

Herpes infections, nausea, vomiting, nasopharyngitis, headache, dizziness, GI upset, acne, increased blood creatinine phosphokinase, UTI, fatigue, oropharyngeal pain, influenza, impetigo, hypertension, contact dermatitis, upper abdominal pain, thrombocytopaenia.

Risk Factor (Pregnancy/Lactation)

Contraindications: Severe hepatic impairment. Severe renal impairment, end-stage renal disease. Active serious infection incl TB. Platelet count <150 x 109/L, absolute neutrophil count <1 x 109/L, absolute lymphocyte count <0.5 x 109/L, or Hb <8g/dL. Rheumatoid arthritis. Patients with active serious infection including localized infection. Patients taking antiplatelet therapies, except for low-dose aspirin (=81 mg daily), during the first 3 months of treatment. Pregnancy. Lactation. Precautions: Moderate or severe renal impairment (eGFR <60ml/min). History of recurrent, serious or opportunistic infection, predisposition to infection, previous travel or residence in areas of endemic mycoses or TB, exposure to TB. Monitor closely for infection during and after treatment; interrupt treatment if infection does not respond to antimicrobial therapy. Screen for TB before starting abrocitinib.…

Interactions

Strong CYP2C19 or CYP2C9 inhibitors (eg, SSRIs, fluconazole), moderate or strong CYP2C19 or CYP2C9 inducers (eg, rifampicin, phenytoin), P-gp substrates (eg, dabigatran, digoxin, ciclosporin), MAOIs, live vaccines, other JAK inhibitors, biologic immunomodulators, other immunosuppressants.

Advice to Patient

Take with or without meals at approximately the same time each day. Swallow tablets whole with water. Do not crush, split, or chew. If a dose is missed, administer the dose as soon as possible unless it is less than 12 hours before the next dose, in which case skip the missed dose. Thereafter, resume dosing at the regular scheduled time. Females of reproductive potential must use effective contraception during treatment and continue for 4 weeks after treatment. Report signs and symptoms of blood clot, including swelling, pain or tenderness in one or both legs, sudden, unexplained chest or upper back pain, shortness of breath or difficulty breathing. Report symptoms of heart attack and stroke, including discomfort in the center of your chest that lasts for more than a few minutes, or that goes away and comes back, severe tightness/pain/pressure/heaviness in your chest/throat/neck/jaw,…

Pharmacokinetics

Absorption: Oral: 91%. Bioavailability: Oral: Approx. 60%. Metabolism: Hepatic. Half-life elimination: 3-5 hrs. Time to peak, plasma: Within 1 hr. Excretion: Urine.

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.